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KMID : 0363220080460030394
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Korean Journal of Dermatology
2008 Volume.46 No. 3 p.394 ~ p.396
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A Case of Erythema Nodosum-Like Eruptions as a Manifestationof Azathioprine Hypersensitivity
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Hwang Chul
Jeon Eun-Kyung
Cho Ah-Young
Jang Sun-Hyae
Seo Young-Joon
Park Jang-Kyu
Lee Jeung-Hoon
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Abstract
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Azathioprine is an immunosuppressant that has been widely used in the prevention of organ post-transplantation rejection, rheumatoid arthritis, inflammatory bowel disease and myasthenia gravis. The adverse effects reported with this drug have been classified as early events that include fever, hypotension, vasculitis and erythema nodosum-like eruptions or as late events that include bone marrow depression, nausea and vomiting. Although erythema nodosumlike eruptions could be useful for recognition of azathioprine hypersensitivity, this eruption has not yet been reported in Korean dermatological literature. We report, herein, a 68-year-old female with myasthenia gravis, who presented with tender, erythema nodosum-like eruptions on both upper and lower extremities 14 days after the first administration of azathioprine. Her symptoms improved 2 days after discontinuation of azathioprine and healed with no scarring change. (Korean J Dermatol 2008;46(3):394∼396)
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KEYWORD
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Azathioprine hypersensitivity, Erythema nodosum
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